Do Natural Ingredients Actually Work Better for Skin Health?

I keep seeing a lot of discussions about natural skincare ingredients versus lab formulated products, and opinions seem very divided.

For those who have tried both approaches, do natural ingredients like plant extracts actually provide better long term results, or is it more about specific active compounds regardless of whether they are natural or synthetic?

I would be interested in hearing real experiences or evidence based opinions on whether natural skincare is genuinely more effective or just better marketed.